高效液相色谱-电化学检测法在药物分析中的应用

程军, 刘延

中国药学杂志 ›› 2017, Vol. 52 ›› Issue (20) : 1753-1771.

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中国药学杂志 ›› 2017, Vol. 52 ›› Issue (20) : 1753-1771. DOI: 10.11669/cpj.2017.20.001
高效液相色谱电化学检测与药物质量控制专栏

高效液相色谱-电化学检测法在药物分析中的应用

  • 程军, 刘延
作者信息 +

Electrochemical Detection in High Performance Liquid Chromatography for Analysis of Pharmaceutical Drugs

  • CHENG Jun, LIU Yan
Author information +
文章历史 +

摘要

基于电化学检测法具有无需衍生、高灵敏度、高选择性以及成本低的特点,高效液相色谱-电化学检测法(HPLC-ED)已经成为药物分析的重要工具。从HPLC-ED技术开始使用40年以来,已有大量相关文章和综述发表。本文将对应用在HPLC中的电化学检测器和检测方法进行回顾,重点介绍HPLC-ED技术在药物分析中的最新研究进展,并讨论这种技术的未来发展趋势。

Abstract

High performance liquid chromatography-electrochemical detection (HPLC-ED)is an important analytical tool for the determination of pharmaceutical drugs since electrochemical detectors provides derivertization-free, sensitive, selective, and low cost detection methods. Numerous papers and reviews have been published since the HPLC-ED techniques were introduced forty years ago. This article will review the electrochemical instruments and detection methods used in HPLC, and focus on recent advances in the analysis of pharmaceutical drugs using HPLC-ED techniques, and discuss the future development trend of the techniques.

关键词

高效液相色谱 / 电化学检测法 / 药物分析 / 流通池 / 脉冲安培检测

Key words

high performance liquid chromatography (HPLC) / electrochemical detection (ED) / drug analysis / flow cell / pulsed amperometric detection(PAD)

引用本文

导出引用
程军, 刘延. 高效液相色谱-电化学检测法在药物分析中的应用[J]. 中国药学杂志, 2017, 52(20): 1753-1771 https://doi.org/10.11669/cpj.2017.20.001
CHENG Jun, LIU Yan. Electrochemical Detection in High Performance Liquid Chromatography for Analysis of Pharmaceutical Drugs[J]. Chinese Pharmaceutical Journal, 2017, 52(20): 1753-1771 https://doi.org/10.11669/cpj.2017.20.001
中图分类号: R917   

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